Adrenocorticotropic hormone, oral steroids superior for new-onset infantile spasms

adrenocorticotropic hormone oral steroids superior for new onset infantile spasms

Sumary of Adrenocorticotropic hormone, oral steroids superior for new-onset infantile spasms:

  • July 28, 2021 3 min read Source/Disclosures Disclosures: Grinspan reports serving as a paid consultant for Alpha Insights and Bio-Pharm Solutions (South Korea) and receiving research support from the Morris and Alma Schapiro Fund, the Pediatric Epilepsy Research Foundation and Weill Cornell Medicine.
  • Please see the study for all other researchers’ relevant financial disclosures.
  • Back to Healio Adrenocorticotropic hormone and oral steroids demonstrated superiority compared with non-standard therapy for the initial treatment of infantile spams in a prospective, multicenter observational cohort study published in Neurology.
  • “Our published analysis of a rigorous prospective multicentered observational study of infants with infantile spasms (the National Infantile Spasms Consortium;
  • ” The researchers also pointed to other concerns about the analysis, including poor inter-rater reliability with a primary outcome as well as the possibility that responses rates “may not be appreciably different between ACTH (or tetracosactide) and oral steroids,” which provided additional support for a reanalysis.
  • Study results demonstrated that rates of freedom from treatment failure were 46% with ACTH (88/190), 44% with oral steroids (42/95), 37% with vigabatrin (32/87) and 8% with non-standard therapy (4/51).

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