Potential lupus treatment reduces organ damaging corticosteroid use


Sumary of Potential lupus treatment reduces organ damaging corticosteroid use:

  • IStock-Anna Fomenko The treatment anifrolumab has been found to reduce lupus flares whilst allowing for patients to reduce the use of corticosteroids that can cause organ damage..
  • Patients with systematic lupus erythematosus, an autoimmune disease in which the immune system attacks healthy tissue in the body, often must use high doses of corticosteroids which are associated with organ damage..
  • A new analysis of the TULIP (Treatment of Uncontrolled Lupus via the Interferon Pathway) clinical trial programme has shown that treatment with anifrolumab, a potential first-in-class type I interferon inhibitor, resulted in a greater reduction in disease flares while having a sustained reduction in doses of oral corticosteroids compared to placebo, with both groups of patients receiving standard therapy..
  • There has been only one medicine approved for systematic lupus erythematosus in the last 60 years, making this a huge advancement in potential treatment for patients..
  • Improving lupus treatment Oral corticosteroids are often used in standard lupus treatment, but long-term use can increase the risk of organ damage and other significant side effects including a higher risk of infections, cardiovascular disease, osteoporosis, and cataracts..
  • Higher doses of corticosteroids are associated with increased organ damage in patients with systemic lupus erythematosus..
  • “A leading treatment goal for systemic lupus erythematosus patients is to prevent flares while also averting the short- and long-term health consequences that can result from treatment with oral corticosteroids…

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