Early cytomegalovirus reactivation after allogeneic HSCT may help prevent future infection

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Sumary of Early cytomegalovirus reactivation after allogeneic HSCT may help prevent future infection:

  • Early cytomegalovirus reactivation after allogeneic stem cell transplantation induced cytomegalovirus antigen-specific T cells that may better prevent future infection, according to results of a retrospective study..
  • The findings, published in Biology of Blood and Marrow Transplantation, suggest that low-level cytomegalovirus (CMV) infection within 100 days of transplantation may be beneficial and may not require treatment until progression of CMV reactivation, researchers noted..
  • CMV reactivation, defined as a viral replication in the blood, and CMV disease, defined as end-organ damage related to the virus, are causes of morbidity and mortality after allogeneic HSCT..
  • Previous studies have suggested CMV reactivation after allogeneic HSCT may have a beneficial effect on immune reconstitution..
  • McCarthy and colleagues analyzed 775 CMV antigen-specific T cell (CAST) measurements collected before transplant and 30, 100 and 365 days after transplant from 327 patients who underwent treatment between 2008 and 2016..
  • Among transplant recipients at a high risk for CMV reactivation with a maximum of grade 2 acute graft-versus-host disease, reactivating CMV before day 100 and achieving three or greater vs…

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