Sumary of Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo:
- In this faction, the viral load in the brain was often undetectable, but this was not correlated with a higher endurance compared to controls.
- Subsets of mice were humanely euthanized at 2 and 5 dpc and different tissues were collected.
- Three hours after the viral contest, the mice were treated with GC-376 or a vehicle for seven days.
- However, the brain samples in GC-376-treated groups showed reduced viral loads, though the variation between individuals in the low-virus contest GC-376-treatment groups was considerable.