Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

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Sumary of Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo:

  • In this faction, the viral load in the brain was often undetectable, but this was not correlated with a higher endurance compared to controls.
  • Subsets of mice were humanely euthanized at 2 and 5 dpc and different tissues were collected.
  • Three hours after the viral contest, the mice were treated with GC-376 or a vehicle for seven days.
  • However, the brain samples in GC-376-treated groups showed reduced viral loads, though the variation between individuals in the low-virus contest GC-376-treatment groups was considerable.

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