Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in huma…

can transgenic mice studies illuminate neurological complications associated with sars cov 2 in humans

Sumary of Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in huma…:

  • The basis for such use is the common hACE2 receptor shared by cells of this mouse and humans, as well as the lethal expression of SARS-CoV-2.
  • This includes a mouse version that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2).
  • Moderate interstitial pneumonia Related Stories The study also showed some degree of interstitial pneumonia, with both viral antigens and RNA being found in the lung parenchyma, within type I alveolar lung cells for the most part.
  • The researchers also found that while hACE2 mRNA was found in cortical neuron clusters and other parts of the brain, murine ACE2 was expressed in the endothelium of the brain’s blood vessels.

bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

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