SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds

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Sumary of SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds:

  • SARS-CoV-2 has the highest transmission rate among the coronaviruses that have caused outbreaks in the past.
  • Apart from the spike (S) region, the genomic regions of open reading frame (ORF)14, ORF9b, ORF8, and ORF3a appear to be highly variable between clinical isolates of SARS-CoV-2.
  • SARS-CoV-2 contains 29 different proteins, which include 16 nonstructural proteins.
  • The reason why SARS-CoV-2 has the highest rate of transmissibility is that it has genetic alterations in the various structural and nonstructural proteins.

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