Sumary of Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing:
- In a recent groundbreaking study, researchers from Stanford University demonstrated the potential of multiplexed targeted next-generation sequencing assay for detecting SARS-CoV-2 genetic fingerprints used in mutation profiling, with the potential of massive scalability required for population studies..
- The source of the rampant coronavirus disease (COVID-19) pandemic is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contains a single-stranded RNA molecule as its genetic material..
- The rising availability of SARS-CoV-2 genome sequences represents a rich resource for biomedical and clinical researchers to delve deep into investigating pandemic spread..
- Leveraging thousands of sequenced SARS-CoV-2 genomes, a research group from Stanford University in the United States (led by Dr. Billy T..
- Framework for identifying population-level SARS-CoV-2 strains and lower frequency quasispecies through pangenome analysis..
- (B) This knowledge can fuel epidemiological studies and allow scientists to characterize major SARS-CoV-2 strains..
- The mutation profile from pangenome analysis allows us to examine whether these mutations create a unique genetic profile that can be traced to and across individuals Identifying mutations and specific viral signatures Related Stories To identify conserved regions across thousands of SARS-CoV-2 genome assemblies, the researchers have developed a stringent computational workflow that analyzes k-mer sequences that are specific viral signatures (i.e., short tracts of sequence) – most notably when a set of genomic elements are compared..
- Based on their identification of conserved regions of the SARS-CoV-2 pangenome, they have subsequently developed a sequencing assay in order to identify novel mutations….