Systemic autoimmune rheumatic disease linked to higher end-organ failure risk in COVID-19


Sumary of Systemic autoimmune rheumatic disease linked to higher end-organ failure risk in COVID-19:

  • Patients with systemic autoimmune rheumatic diseases who contract COVID-19 may have a higher risk for end-organ failure than those without such diseases, according to a speaker at ACR Convergence 2020..
  • “Patients with rheumatic diseases and their providers continue to have concerns regarding the potentially increased risk for poor COVID-19 outcomes due to underlying immunosuppression, a chronic inflammatory state, comorbidities and racial, ethnic and socioeconomic disparities,”.
  • “Early center-specific studies from Wuhan, China, and Boston, Massachusetts, reported up to three-fold higher odds of mechanical ventilation in patients with rheumatic disease versus comparators.”.
  • “Patients with rheumatic disease appear to be at higher risk of some severe COVID-19 outcomes, including hospitalization, intensive care unit admission and renal failure, and this is likely mediated largely by comorbidities,”.
  • To examine whether patients with systemic autoimmune rheumatic diseases demonstrate more severe COVID-19 complications, D ilva and colleagues conducted a matched cohort study using the TriNETX Research Network..
  • According to the researchers, this network includes real-time electronic health record data from more than 52 million patients across 35 health care organizations..
  • Systemic autoimmune rheumatic disease was defined as rheumatoid arthritis, systemic lupus erythematosus, Sjogren syndrome, systemic sclerosis, idiopathic inflammatory myositis, mixed or undifferentiated connective tissue disease, systemic vasculitis, psoriatic arthritis, or ankylosing spondylitis, and identified through two ICD-10 codes greater than 2 months apart..
  • For the comparison cohort, D ilva and colleagues matched one individual without systemic autoimmune rheumatic disease based on age, sex and race or ethnicity..
  • In all, the researchers included 716 patients with COVID-10 and systemic autoimmune rheumatic diseases, and 716 matched comparators, in their analysis..
  • The distribution of rheumatic disease was 45% with RA, 18% with SLE, 10% with Sjogren syndrome, 3% with SSc, 3% with idiopathic inflammatory myositis, 5% with mixed or undifferentiated connective tissue disease, 9% with systemic vasculitis, with 6% PsA and 3% with AS….

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